3-乙炔基-1-甲基-1H-吲哚合成路线 （共 10 条）
反应条件
sodium hydroxide in tetrahydrofuran
Reflux;
参考文献
Gupton, John T.; Telang, Nakul; Gazzo, Dominic F.; Barelli, Peter J.; Lescalleet, Kristin E.; Fagan, Jonathan W.; Mills, Brandon J.; Finzel, Kara L.; Kanters, Rene P.F.; Crocker, Kyle R.; Dudek, Sean T.; Lariviere, Corinne M.; Smith, Stanton Q.; Keertikar, Kartik M.
Tetrahedron, 2013 , vol. 69, # 29 p. 5829 - 5840
反应条件
potassium hydroxide
T=120 - 130°C; P=1.5 Torr;
参考文献
Shvartsberg, M. S.; Vasilevskii, S. F.; Prikhod'ko, T. A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1982 , vol. 31, # 11 p. 2226 - 2229
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1982 , # 11 p. 2524 - 2527
反应条件
T=600°C; P=0.001 - 0.01 Torr;
参考文献
Benzies, David W. M.; Fresneda, Pilar Martinez; Jones, R. Alan; McNab, Hamish
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1651 - 1654
参考文献
Barluenga, Jose; Fananas-Mastral, Martin; Angel Palomero; Aznar, Fernando; Valdes, Carlos
Chemistry - A European Journal, 2007 , vol. 13, # 27 p. 7682 - 7700
反应条件
1: 53.2 percent / K2CO3, (Ph3P)2PdCl2, CuI / pyridine / 36 h / 60 °C
2: 57.3 percent / KOH / 120 - 130 °C / 1.5 Torr
View Scheme
参考文献
Shvartsberg, M. S.; Vasilevskii, S. F.; Prikhod'ko, T. A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1982 , vol. 31, # 11 p. 2226 - 2229
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1982 , # 11 p. 2524 - 2527
反应条件
1: 73 percent / ICl / dioxane; pyridine / 0.17 h / 0 °C
2: 53.2 percent / K2CO3, (Ph3P)2PdCl2, CuI / pyridine / 36 h / 60 °C
3: 57.3 percent / KOH / 120 - 130 °C / 1.5 Torr
View Scheme
参考文献
Shvartsberg, M. S.; Vasilevskii, S. F.; Prikhod'ko, T. A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1982 , vol. 31, # 11 p. 2226 - 2229
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1982 , # 11 p. 2524 - 2527
反应条件
1: 93 percent / acetic acid, piperidine / benzene / 24 h / 20 °C
2: 19.6 percent / 600 °C / 0 - 0.01 Torr
View Scheme
参考文献
Benzies, David W. M.; Fresneda, Pilar Martinez; Jones, R. Alan; McNab, Hamish
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1651 - 1654
反应条件
1.1: trichlorophosphate / dichloromethane / 2 h / |Reflux
1.2: 24 h / 20 °C
2.1: sodium hydroxide / tetrahydrofuran / |Reflux
View Scheme
参考文献
Gupton, John T.; Telang, Nakul; Gazzo, Dominic F.; Barelli, Peter J.; Lescalleet, Kristin E.; Fagan, Jonathan W.; Mills, Brandon J.; Finzel, Kara L.; Kanters, Rene P.F.; Crocker, Kyle R.; Dudek, Sean T.; Lariviere, Corinne M.; Smith, Stanton Q.; Keertikar, Kartik M.
Tetrahedron, 2013 , vol. 69, # 29 p. 5829 - 5840
反应条件
1: potassium hydroxide; iodine / N,N-dimethyl-formamide
2: sodium hydride / N,N-dimethyl-formamide
3: triphenylphosphine; tris-(dibenzylideneacetone)dipalladium(0); copper(l) iodide; triethylamine / toluene / 1 h / 20 °C / |Inert atmosphere
4: tetrabutyl ammonium fluoride / dichloromethane / 0.17 h
View Scheme
参考文献
Thorley, Karl J.; Hales, Joel M.; Kim, Hyeongeu; Ohira, Shino; Bredas, Jean-Luc; Perry, Joseph W.; Anderson, Harry L.
Chemistry - A European Journal, 2013 , vol. 19, # 31 p. 10370 - 10377
反应条件
1: sodium hydride / N,N-dimethyl-formamide
2: triphenylphosphine; tris-(dibenzylideneacetone)dipalladium(0); copper(l) iodide; triethylamine / toluene / 1 h / 20 °C / |Inert atmosphere
3: tetrabutyl ammonium fluoride / dichloromethane / 0.17 h
View Scheme
参考文献
Thorley, Karl J.; Hales, Joel M.; Kim, Hyeongeu; Ohira, Shino; Bredas, Jean-Luc; Perry, Joseph W.; Anderson, Harry L.
Chemistry - A European Journal, 2013 , vol. 19, # 31 p. 10370 - 10377
