1-苄基-4-(苯胺基)哌啶-4-羧酸合成路线 （共 12 条）
反应条件
potassium hydroxide in ethylene glycol T=20 - 210°C; 3 h;
参考文献
Srimurugan, Sankareswaran; Murugan, Kaliyappan; Chen, Chinpiao
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 12 p. 1421 - 1424
反应条件
1: 77 percent / H2SO4 / 16 h / 20 °C 2: 76 percent / KOH / ethane-1,2-diol / 16 h / 190 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 24 p. 7720 - 7732
反应条件
1: 58 percent / aq. AcOH / 48 h / 20 °C 2: 77 percent / H2SO4 / 16 h / 20 °C 3: 76 percent / KOH / ethane-1,2-diol / 16 h / 190 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 24 p. 7720 - 7732
反应条件
1: 58 percent / aq. AcOH / 48 h / 20 °C 2: 77 percent / H2SO4 / 16 h / 20 °C 3: 76 percent / KOH / ethane-1,2-diol / 16 h / 190 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 24 p. 7720 - 7732
反应条件
triethylamine in ethyl acetate Acylation; 1 h; Heating;
参考文献
Coleman, Mark J.; Goodyear, Michael D.; Latham, David W. S.; Whitehead, Andrew J.
Synlett, 1999 , # 12 p. 1923 - 1924
反应条件
1.1: NaH / dimethylformamide 1.2: 42 percent / dimethylformamide / 48 h / 20 °C 2.1: 23 percent / 6 h / Heating View Scheme
参考文献
Coleman, Mark J.; Goodyear, Michael D.; Latham, David W. S.; Whitehead, Andrew J.
Synlett, 1999 , # 12 p. 1923 - 1924
反应条件
1: 4-phenylamino-1-benzyl-4-piperidinecarboxylic acid With sodium hydride in N,N-dimethyl-formamide 2: methyl iodide in N,N-dimethyl-formamide 3: propionic acid anhydride in N,N-dimethyl-formamide 72 h; Reflux;
参考文献
Butcher, Ken J.; Hurst, Jenny
Tetrahedron Letters, 2010 , vol. 51, # 50 p. 6677 - 6678
反应条件
1: 4-phenylamino-1-benzyl-4-piperidinecarboxylic acid With sodium hydride in N,N-dimethyl-formamide 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 48 h;
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 24 p. 7720 - 7732
反应条件
1.1: NaH / dimethylformamide 1.2: 42 percent / dimethylformamide / 48 h / 20 °C 2.1: 23 percent / 6 h / Heating 3.1: 52 percent / H2 / Pd/C / ethanol / 24 h / 20 °C View Scheme
参考文献
Henriksen, Gjermund; Platzer, Stefan; Marton, Janos; Hauser, Andrea; Berthele, Achim; Schwaiger, Markus; Marinelli, Luciana; Lavecchia, Antonio; Novellino, Ettore; Wester, Hans-Juergen
Journal of Medicinal Chemistry, 2005 , vol. 48, # 24 p. 7720 - 7732
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0°C; Inert atmosphereReflux;
参考文献
Srimurugan, Sankareswaran; Murugan, Kaliyappan; Chen, Chinpiao
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 12 p. 1421 - 1424
