1-苄基-4-(苯胺基)哌啶-4-羧酸合成路线 （共 12 条）
反应条件
1: 4-phenylamino-1-benzyl-4-piperidinecarboxylic acid With sodium hydroxide in methanol
0.5 h; Heating / reflux;
2: ethyl bromide in N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=20°C;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2006/105035 A2, 2006 ;
Location in patent: Page/Page column 56-57 ;
WO 2006/105035 A2
反应条件
in toluene
240 h; Heating;
参考文献
Colapret; Diamantidis; Spencer; Spaulding; Rudo
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 968 - 974
