4-氨基-1-[2-(4-甲氧基苯基)乙基]哌啶合成路线 （共 6 条）
反应条件
ammonia; hydrogen; palladium on activated charcoal in methanol
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 12 p. 1925 - 1933
反应条件
1: sodium carbonate, potassium iodide / various solvent(s) / 18 h / Heating 2: 2 N HCl / Heating 3: H2, NH3 / 10 percent Pd/C / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 12 p. 1925 - 1933
反应条件
1: 2 N HCl / Heating 2: H2, NH3 / 10 percent Pd/C / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 12 p. 1925 - 1933
反应条件
1: triethylamine / tetrahydrofuran / |Reflux 2: trifluoroacetic acid / dichloromethane / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 7 p. 1830 - 1838
反应条件
1: triethylamine / tetrahydrofuran / |Reflux 2: trifluoroacetic acid / dichloromethane / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 7 p. 1830 - 1838
反应条件
1: With sodium hydroxide in water 1 h; 2: With chloroformic acid ethyl ester in water T=70 - 80°C; 2 h;
参考文献
Roman, Gheorghe; Crandall, Ian E.; Szarek, Walter A.
ChemMedChem, 2013 , vol. 8, # 11 p. 1795 - 1804
