(5-异丙氧基吡啶-3-基)硼酸合成路线 (共 1 条)
反应条件
1: 3-bromo-5-isopropoxypyridine With n-butyllithium in toluene
T=-78 - -50°C; 0.5 h;
2: tri-isopropoxy-borane in tetrahydrofuran; toluene
T=-78 - -15°C; 0.25 h;
3: With hydrogenchloride; sodium hydroxide; water
more than 3 stages;
参考文献
TARGACEPT, INC.
Patent: WO2006/34089 A1, 2006 ;
Location in patent: Page/Page column 63 ;
WO 2006/034089 A1