1: With potassium tert-butylate in toluene T=60°C; 25 h; 2: With hydrogenchloride; water; acetic acid T=85°C; 4 h; 3: With sodium hydroxide in water T=20°C; pH=10;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/37796 A1, 2005 ;
Location in patent: Page/Page column 142 ;