4-(4-四氢吡喃氧基)苯甲酸合成路线 （共 4 条）
反应条件
sodium hydroxide; water in ethanol T=60°C; 5 h;
参考文献
WO2005/40144 A1, ;
Page/Page column 11-12 ;
WO 2005/040144 A1
反应条件
1: With water; sodium hydroxide in toluene T=80°C; 2: With hydrogenchloride pH=1;
参考文献
WO2010/18231 A2, ;
Page/Page column 33-35 ;
反应条件
1: With methanol; sodium hydroxide; water T=20°C; 4 h; Heating / reflux; 2: With hydrogenchloride; water pH=2; Product distribution / selectivity;
参考文献
WO2009/30716 A1, ;
Page/Page column 31-32 ;
WO 2009/030716 A1
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=20°C; 1 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/30716 A1, 2009 ;
Location in patent: Page/Page column 36 ;
WO 2009/030716 A1
