3,5-二氟-2-肼基吡啶合成路线 （共 8 条）
反应条件
1.1: 79 percent / aq. CuSO4 / Heating 2.1: BuLi / tetrahydrofuran; hexane 2.2: 73 percent / hexachloroethane / tetrahydrofuran; hexane View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
copper(II) sulfate Heating;
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
1.1: 79 percent / aq. CuSO4 / Heating 2.1: BuLi / tetrahydrofuran; hexane 2.2: 73 percent / hexachloroethane / tetrahydrofuran; hexane 3.1: 51 percent / KF; tetramethylammonium chloride / dimethylsulfoxide / 6 h / 150 °C View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
1: With bromine in chloroform T=40 - 60°C; 1.25 h; Heating / reflux; 2: With sodium hydrogencarbonate in chloroform T=0°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/132502 A1, 2008 ;
Location in patent: Page/Page column 87 ;
WO 2008/132502 A1
反应条件
hydrazine in propan-1-ol
6 h; Heating / reflux;
参考文献
Park, Tae-Ho; Zhao, Long-Xuan; Lee, Sang-Ho
Patent: US2006/47124 A1, 2006 ;
Location in patent: Page/Page column 3 ;
US 20060047124 A1
反应条件
1: 65 percent / aq. CuSO4 / Heating
2: 68 percent / hydrazine monohydrate / ethanol / 6 h / Heating
View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
1: 88 percent / hydrazine monohydrate / ethanol / 2 h / Heating
2: 65 percent / aq. CuSO4 / Heating
3: 68 percent / hydrazine monohydrate / ethanol / 6 h / Heating
View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
1: 90 percent / Zn; aq. ammonia / 6 h / 0 °C
2: 88 percent / hydrazine monohydrate / ethanol / 2 h / Heating
3: 65 percent / aq. CuSO4 / Heating
4: 68 percent / hydrazine monohydrate / ethanol / 6 h / Heating
View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
