3-(苄基(3-乙氧基-3-氧代丙基)氨基)-2,2-二氟丙酸乙酯合成路线 （共 5 条）
反应条件
1: lithium diisopropyl amide / tetrahydrofuran; hexane / -78 - 20 °C 2: hydrogenchloride; water / 3 h / 110 °C View Scheme
参考文献
GLAXOSMITHKLINE LLC; ADAMS, Nicholas, David; CHAUDHARI, Amita, M.; KIESOW, Terence, John; McSHERRY, Allison, K.; MOORE, Michael, Lee; PARRISH, Cynthia, Ann; REIF, Alexander, Joseph; RIDGERS, Lance, Howard
Patent: WO2014/8223 A2, 2014 ;
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; Dieckmann Reaction;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2005/40120 A1, 2005 ;
Location in patent: Page/Page column 18; 31 ;
WO 2005/040120 A1
反应条件
1: bromo-difluoroacetic acid,ethyl ester With chloro-trimethyl-silane; zinc in tetrahydrofuran
0.166667 h;
2: ethyl N-(1H-1,2,3-benzotriazol-1-ylmethyl)-N-(phenylmethyl)-beta-alaninate in tetrahydrofuran
T=20°C; 18 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2005/40120 A1, 2005 ;
Location in patent: Page/Page column 18; 31 ;
WO 2005/040120 A1
反应条件
chloro-trimethyl-silane; zinc in tetrahydrofuran
2 h;
参考文献
Fujimoto, Tatsuhiko; Tomata, Yoshihide; Kunitomo, Jun; Hirozane, Mariko; Marui, Shogo
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6409 - 6413
反应条件
1: methanol; water / 16 h / 20 °C
2: chloro-trimethyl-silane; zinc / tetrahydrofuran / 2 h
View Scheme
参考文献
Fujimoto, Tatsuhiko; Tomata, Yoshihide; Kunitomo, Jun; Hirozane, Mariko; Marui, Shogo
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6409 - 6413
