1-苯基-8-[(1S,2S)-2-苯基环己基]-1,3,8-三氮杂螺[4.5]癸烷-4-酮合成路线 （共 3 条）
反应条件
1.1: TsOH / toluene / Heating
1.2: 70 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane / 20 °C
2.1: 70 percent / aq. HCl / methanol / Heating
3.1: AcOH / H2O / 20 °C
4.1: aq. H2SO4 / 20 °C
5.1: AcOH / toluene / 48 h / Heating
6.1: separation on chiral-phase HPLC (Chiralpack AD)
View Scheme
参考文献
Pinard, Emmanuel; Ceccarelli, Simona M.; Stalder, Henri; Alberati, Daniela
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 349 - 353
反应条件
1.1: aq. Dess-Martin periodinane / CH2Cl2 / 20 °C
2.1: TsOH / toluene / Heating
2.2: 70 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane / 20 °C
3.1: 70 percent / aq. HCl / methanol / Heating
4.1: AcOH / H2O / 20 °C
5.1: aq. H2SO4 / 20 °C
6.1: AcOH / toluene / 48 h / Heating
7.1: separation on chiral-phase HPLC (Chiralpack AD)
View Scheme
参考文献
Pinard, Emmanuel; Ceccarelli, Simona M.; Stalder, Henri; Alberati, Daniela
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 349 - 353
反应条件
1.1: CuBr*Me2S / tetrahydrofuran / 0 °C
2.1: aq. Dess-Martin periodinane / CH2Cl2 / 20 °C
3.1: TsOH / toluene / Heating
3.2: 70 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane / 20 °C
4.1: 70 percent / aq. HCl / methanol / Heating
5.1: AcOH / H2O / 20 °C
6.1: aq. H2SO4 / 20 °C
7.1: AcOH / toluene / 48 h / Heating
8.1: separation on chiral-phase HPLC (Chiralpack AD)
View Scheme
参考文献
Pinard, Emmanuel; Ceccarelli, Simona M.; Stalder, Henri; Alberati, Daniela
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 349 - 353
