4'-(2-呋喃基)-[4,5'-联嘧啶]-2'-胺合成路线 （共 5 条）
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide)
T=70°C; 20 h;
参考文献
ALMIRALL PRODESFARMA, S.A.
Patent: WO2005/40155 A1, 2005 ;
Location in patent: Page/Page column 19 ;
WO 2005/040155 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=70°C; 20 h;
参考文献
Vidal, Bernat; Nueda, Arsenio; Esteve, Cristina; Domenech, Teresa; Benito, Sonia; Reinoso, Raquel F.; Pont, Merce; Calbet, Marta; Lopez, Rosa; Cadavid, Maria Isabel; Loza, Maria Isabel; Cardenas, Alvaro; Godessart, Nuria; Beleta, Jorge; Warrellow, Graham; Ryder, Hamish
Journal of Medicinal Chemistry, 2007 , vol. 50, # 11 p. 2732 - 2736
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=70°C;
参考文献
Eastwood, Paul; Gonzalez, Jacob; Paredes, Sergio; Nueda, Arsenio; Domenech, Teresa; Alberti, Joan; Vidal, Bernat
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 5 p. 1697 - 1700
反应条件
1: 85 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran; hexane / 3 h / 0 - 20 °C
2: 75 percent / 2 h / 100 °C
3: 61 percent / potassium carbonate / dimethylformamide / 20 h / 70 °C
View Scheme
参考文献
Vidal, Bernat; Nueda, Arsenio; Esteve, Cristina; Domenech, Teresa; Benito, Sonia; Reinoso, Raquel F.; Pont, Merce; Calbet, Marta; Lopez, Rosa; Cadavid, Maria Isabel; Loza, Maria Isabel; Cardenas, Alvaro; Godessart, Nuria; Beleta, Jorge; Warrellow, Graham; Ryder, Hamish
Journal of Medicinal Chemistry, 2007 , vol. 50, # 11 p. 2732 - 2736
反应条件
1: 75 percent / 2 h / 100 °C
2: 61 percent / potassium carbonate / dimethylformamide / 20 h / 70 °C
View Scheme
参考文献
Vidal, Bernat; Nueda, Arsenio; Esteve, Cristina; Domenech, Teresa; Benito, Sonia; Reinoso, Raquel F.; Pont, Merce; Calbet, Marta; Lopez, Rosa; Cadavid, Maria Isabel; Loza, Maria Isabel; Cardenas, Alvaro; Godessart, Nuria; Beleta, Jorge; Warrellow, Graham; Ryder, Hamish
Journal of Medicinal Chemistry, 2007 , vol. 50, # 11 p. 2732 - 2736
