1-甲基-1,2,3,4-四氢喹啉-4-胺合成路线 （共 4 条）
反应条件
ammonia; hydrogen; nickel in methanol
T=20°C; P=3102.97 Torr; 4 h; glass reactor sealed;
参考文献
Abbott Laboratories
Patent: US2008/153871 A1, 2008 ;
Location in patent: Page/Page column 27 ;
反应条件
hydrogen; 10 Pd(OH)2/C in methanol
T=20°C; 1.5 h;
参考文献
FUJISAWA PHARMACEUTICAL CO., LTD.
Patent: WO2005/42533 A2, 2005 ;
Location in patent: Page/Page column 121 ;
WO 2005/042533 A2
反应条件
1: With sodium tris(acetoxy)borohydride in water; acetonitrile
T=20°C; 18 h;
2: With water; trifluoroacetic acid
T=20°C; 0.333333 h;
参考文献
Gomtsyan, Arthur; Bayburt, Erol K.; Schmidt, Robert G.; Lee, Chih-Hung; Brown, Brian S.; Jinkerson, Tammie K.; Koenig, John R.; Daanen, Jerome F.; Latshaw, Steven P.
Patent: US2006/128689 A1, 2006 ;
Location in patent: Page/Page column 50 ;
反应条件
1: pyridine / 24 h / 20 °C
2: ammonia; hydrogen / methanol / 4 h / 20 °C / 3102.97 Torr
View Scheme
参考文献
Schmidt, Robert G.; Bayburt, Erol K.; Latshaw, Steven P.; Koenig, John R.; Daanen, Jerome F.; McDonald, Heath A.; Bianchi, Bruce R.; Zhong, Chengmin; Joshi, Shailen; Honore, Prisca; Marsh, Kennan C.; Lee, Chih-Hung; Faltynek, Connie R.; Gomtsyan, Arthur
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1338 - 1341
