N-(2-硝基苯基)甲烷磺酰胺合成路线 （共 11 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol T=20°C; 18 h;
参考文献
CEPHALON, INC.; PHARMACOPEIA DRUG DISCOVERY, INC.
Patent: WO2008/51547 A1, 2008 ;
Location in patent: Page/Page column 535 ;
WO 2008/051547 A1
反应条件
1: With pyridine
T=20°C; 18 h;
2: With sodium hydroxide in tetrahydrofuran; water
T=20°C; 2 h;
3: With hydrogenchloride in tetrahydrofuran; water
pH=7;
参考文献
CELLZOME LIMITED
Patent: WO2009/112490 A1, 2009 ;
Location in patent: Page/Page column 53 ;
WO 2009/112490 A1
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
T=20°C; 3 h;
参考文献
CEPHALON, INC.; PHARMACOPEIA DRUG DISCOVERY, INC.
Patent: WO2008/51547 A1, 2008 ;
Location in patent: Page/Page column 535 ;
WO 2008/051547 A1
反应条件
1: With triethylamine in dichloromethane
T=20°C;
2: With sodium hydroxide in methanol; water
T=20°C;
参考文献
Greenfield, Alexander; Grosanu, Cristina
Tetrahedron Letters, 2008 , vol. 49, # 44 p. 6300 - 6303
反应条件
tert.-butylnitrite in acetonitrile
T=45°C; 24 h; chemoselective reaction;
参考文献
Kilpatrick, Brenden; Heller, Markus; Arns, Steve
Chemical Communications, 2013 , vol. 49, # 5 p. 514 - 516
反应条件
pyridine
24 h; Ambient temperature;
参考文献
Yasuhara, Akito; Kameda, Mitsuyoshi; Sakamoto, Takao
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 6 p. 809 - 812
参考文献
Degani,J. et al.
Gazzetta Chimica Italiana, 1962 , vol. 92, p. 1204 - 1212
反应条件
1: NOCl, NaOAc, P2O5 / acetic acid; acetic anhydride / 8 °C
2: benzene / 40 °C
View Scheme
参考文献
Degani,J. et al.
Gazzetta Chimica Italiana, 1962 , vol. 92, p. 1204 - 1212
反应条件
potassium tert-butylate in N,N-dimethyl-formamide
15.25 h; Reflux;
参考文献
ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VAN CAMP, Jennifer; XU, Xiangdong; OSUMA, Augustine, Toby; GREGG, Robert; LONGENECKER, Kenton, L.
Patent: WO2012/45195 A1, 2012 ;
Location in patent: Page/Page column 104-105 ;
WO 2012/045195 A1
反应条件
1: pyridine / |Reflux
2: tert.-butylnitrite / acetonitrile / 24 h / 45 °C
View Scheme
参考文献
Kilpatrick, Brenden; Heller, Markus; Arns, Steve
Chemical Communications, 2013 , vol. 49, # 5 p. 514 - 516
