1.1: potassium phosphate; potassium acetate; triphenylphosphine; [Ru(II)(η6-benzene)(μ-Cl)Cl]2 / 1-methyl-pyrrolidin-2-one / 42 h / 110 - 130 °C / |Inert atmosphere 2.1: N-ethyl-N,N-diisopropylamine; methyl chloroformate / tetrahydrofuran / 0.75 h / 62 °C 2.2: 13 h / 0 - 20 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / 5 h / 10 - 20 °C 4.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / -15 - 12 °C View Scheme

1.1: potassium phosphate; [Ru(II)(η6-benzene)(μ-Cl)Cl]2; potassium acetate; triphenylphosphine / 1-methyl-pyrrolidin-2-one / 9 h / 110 - 130 °C / Inert atmosphere; Large scale reaction 2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.75 h / 20 - 62 °C / Inert atmosphere; Large scale reaction 3.1: sodium tetrahydroborate / tetrahydrofuran; water / 17.92 h / 0 - 22 °C / Inert atmosphere; Large scale reaction 3.2: 0 - 20 °C / Inert atmosphere; Large scale reaction View Scheme