(1S,6r)-8-boc-3,8-二氮杂双环[4.2.0]辛烷合成路线 （共 8 条）
反应条件
potassium carbonate in methanol; water
T=20°C; 16 h;
参考文献
Frost, Jennifer M.; Bunnelle, William H.; Tietje, Karin R.; Anderson, David J.; Rueter, Lynne E.; Curzon, Peter; Surowy, Carol S.; Ji, Anquo; Daanen, Jerome F.; Kohlhaas, Kathy L.; Buckley, Michael J.; Henry, Rodger F.; Dyhring, Tino; Ahring, Philip K.; Meyer, Michael D.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7843 - 7853
反应条件
1: trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C
2: 100 percent / triethylamine / tetrahydrofuran / 1.5 h / -30 - -10 °C
3: 100 percent / H2 / Pd(OH)2/C / ethyl acetate / 16.5 h / 50 °C / 3102.89 Torr
4: 98 percent / K2CO3 / methanol; H2O / 16 h / 20 °C
View Scheme
参考文献
Frost, Jennifer M.; Bunnelle, William H.; Tietje, Karin R.; Anderson, David J.; Rueter, Lynne E.; Curzon, Peter; Surowy, Carol S.; Ji, Anquo; Daanen, Jerome F.; Kohlhaas, Kathy L.; Buckley, Michael J.; Henry, Rodger F.; Dyhring, Tino; Ahring, Philip K.; Meyer, Michael D.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7843 - 7853
反应条件
1: 100 percent / H2 / Pd(OH)2/C / ethyl acetate / 16.5 h / 50 °C / 3102.89 Torr
2: 98 percent / K2CO3 / methanol; H2O / 16 h / 20 °C
View Scheme
参考文献
Frost, Jennifer M.; Bunnelle, William H.; Tietje, Karin R.; Anderson, David J.; Rueter, Lynne E.; Curzon, Peter; Surowy, Carol S.; Ji, Anquo; Daanen, Jerome F.; Kohlhaas, Kathy L.; Buckley, Michael J.; Henry, Rodger F.; Dyhring, Tino; Ahring, Philip K.; Meyer, Michael D.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7843 - 7853
反应条件
1: pyridine / CH2Cl2
2: trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C
3: 100 percent / triethylamine / tetrahydrofuran / 1.5 h / -30 - -10 °C
4: 100 percent / H2 / Pd(OH)2/C / ethyl acetate / 16.5 h / 50 °C / 3102.89 Torr
5: 98 percent / K2CO3 / methanol; H2O / 16 h / 20 °C
View Scheme
参考文献
Frost, Jennifer M.; Bunnelle, William H.; Tietje, Karin R.; Anderson, David J.; Rueter, Lynne E.; Curzon, Peter; Surowy, Carol S.; Ji, Anquo; Daanen, Jerome F.; Kohlhaas, Kathy L.; Buckley, Michael J.; Henry, Rodger F.; Dyhring, Tino; Ahring, Philip K.; Meyer, Michael D.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7843 - 7853
反应条件
1: NaBH(OAc)3; acetic acid / toluene / 16 h / 20 °C
2: LiAlH4 / tetrahydrofuran / 1 h / 20 °C
3: pyridine / CH2Cl2
4: trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C
5: 100 percent / triethylamine / tetrahydrofuran / 1.5 h / -30 - -10 °C
6: 100 percent / H2 / Pd(OH)2/C / ethyl acetate / 16.5 h / 50 °C / 3102.89 Torr
7: 98 percent / K2CO3 / methanol; H2O / 16 h / 20 °C
View Scheme
参考文献
Frost, Jennifer M.; Bunnelle, William H.; Tietje, Karin R.; Anderson, David J.; Rueter, Lynne E.; Curzon, Peter; Surowy, Carol S.; Ji, Anquo; Daanen, Jerome F.; Kohlhaas, Kathy L.; Buckley, Michael J.; Henry, Rodger F.; Dyhring, Tino; Ahring, Philip K.; Meyer, Michael D.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7843 - 7853
反应条件
1: LiAlH4 / tetrahydrofuran / 1 h / 20 °C
2: pyridine / CH2Cl2
3: trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C
4: 100 percent / triethylamine / tetrahydrofuran / 1.5 h / -30 - -10 °C
5: 100 percent / H2 / Pd(OH)2/C / ethyl acetate / 16.5 h / 50 °C / 3102.89 Torr
6: 98 percent / K2CO3 / methanol; H2O / 16 h / 20 °C
View Scheme
参考文献
Frost, Jennifer M.; Bunnelle, William H.; Tietje, Karin R.; Anderson, David J.; Rueter, Lynne E.; Curzon, Peter; Surowy, Carol S.; Ji, Anquo; Daanen, Jerome F.; Kohlhaas, Kathy L.; Buckley, Michael J.; Henry, Rodger F.; Dyhring, Tino; Ahring, Philip K.; Meyer, Michael D.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7843 - 7853
反应条件
1: Et3N; H2 / Pd(OH)2/C / ethanol; H2O / 0.42 h / 3102.89 Torr
2: toluene / 36 h / Heating
3: NaBH(OAc)3; acetic acid / toluene / 16 h / 20 °C
4: LiAlH4 / tetrahydrofuran / 1 h / 20 °C
5: pyridine / CH2Cl2
6: trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C
7: 100 percent / triethylamine / tetrahydrofuran / 1.5 h / -30 - -10 °C
8: 100 percent / H2 / Pd(OH)2/C / ethyl acetate / 16.5 h / 50 °C / 3102.89 Torr
9: 98 percent / K2CO3 / methanol; H2O / 16 h / 20 °C
View Scheme
参考文献
Frost, Jennifer M.; Bunnelle, William H.; Tietje, Karin R.; Anderson, David J.; Rueter, Lynne E.; Curzon, Peter; Surowy, Carol S.; Ji, Anquo; Daanen, Jerome F.; Kohlhaas, Kathy L.; Buckley, Michael J.; Henry, Rodger F.; Dyhring, Tino; Ahring, Philip K.; Meyer, Michael D.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7843 - 7853
反应条件
1: toluene / 36 h / Heating
2: NaBH(OAc)3; acetic acid / toluene / 16 h / 20 °C
3: LiAlH4 / tetrahydrofuran / 1 h / 20 °C
4: pyridine / CH2Cl2
5: trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C
6: 100 percent / triethylamine / tetrahydrofuran / 1.5 h / -30 - -10 °C
7: 100 percent / H2 / Pd(OH)2/C / ethyl acetate / 16.5 h / 50 °C / 3102.89 Torr
8: 98 percent / K2CO3 / methanol; H2O / 16 h / 20 °C
View Scheme
参考文献
Frost, Jennifer M.; Bunnelle, William H.; Tietje, Karin R.; Anderson, David J.; Rueter, Lynne E.; Curzon, Peter; Surowy, Carol S.; Ji, Anquo; Daanen, Jerome F.; Kohlhaas, Kathy L.; Buckley, Michael J.; Henry, Rodger F.; Dyhring, Tino; Ahring, Philip K.; Meyer, Michael D.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7843 - 7853
