2,2-二甲基-7-硝基-2H-苯并[b][1,4]噁嗪-3(4h)-酮合成路线 （共 4 条）
反应条件
hydrazine hydrate; nickel in ethanol 2 h; Heating;
参考文献
Shridhar, D. R.; Rao, K. Srinivasa; Singh, A. N.; Rastogi, K.; Jain, M. L.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 1263 - 1267
反应条件
1: 2-amino-5-nitro-phenol With potassium fluoride in N,N-dimethyl-formamide
T=20°C; 1 h;
2: ethyl 2-bromo-2-methyl propionate in N,N-dimethyl-formamide
T=60°C; 20.33 h;
参考文献
TANABE SEIYAKU CO., LTD.
Patent: WO2007/89034 A1, 2007 ;
Location in patent: Page/Page column 73 ;
WO 2007/089034 A1
反应条件
potassium fluoride in N,N-dimethyl-formamide
T=50 - 60°C; 6 h;
参考文献
Shridhar; Gandhi Rao
Synthesis, 1982 , vol. No. 11, p. 986 - 987
反应条件
hydrogen bromide; phenol
参考文献
Norris
Journal of the American Chemical Society, 1959 , vol. 81, p. 4239,4242
