3-溴-5-氯-2-甲氧基-4-甲基吡啶合成路线 （共 4 条）
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide
T=50°C; 20 h;
参考文献
ISHIHARA SANGYO KAISHA, LTD.
Patent: EP1679003 A1, 2006 ;
Location in patent: Page/Page column 15 ;
反应条件
N-chloro-succinimide in N,N-dimethyl-formamide
T=80°C; 3 h;
参考文献
EISAI RandD MANAGEMENT CO., LTD.; Norimine, Yoshihiko; Takeda, Kunitoshi; Hagiwara, Koji; Suzuki, Yuichi; Ishihara, Yuki; Sato, Nobuaki
Patent: US2013/143907 A1, 2013 ;
Location in patent: Paragraph 0479; 0480 ;
反应条件
1: sodium nitrite; hydrogen bromide; bromine / water / 12 h / 0 - 35 °C
2: sodium methylate / N,N-dimethyl-formamide; methanol / 12 h / 100 °C
3: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 80 °C
View Scheme
参考文献
EISAI RandD MANAGEMENT CO., LTD.; Norimine, Yoshihiko; Takeda, Kunitoshi; Hagiwara, Koji; Suzuki, Yuichi; Ishihara, Yuki; Sato, Nobuaki
Patent: US2013/143907 A1, 2013 ;
反应条件
1: sodium methylate / N,N-dimethyl-formamide; methanol / 12 h / 100 °C
2: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 80 °C
View Scheme
参考文献
EISAI RandD MANAGEMENT CO., LTD.; Norimine, Yoshihiko; Takeda, Kunitoshi; Hagiwara, Koji; Suzuki, Yuichi; Ishihara, Yuki; Sato, Nobuaki
Patent: US2013/143907 A1, 2013 ;
