2-(4-氟苯基)-5-(3-噻吩基)-4-恶唑乙酸合成路线 （共 5 条）
反应条件
potassium hydroxide in methanol
24 h; Ambient temperature;
参考文献
Tanabe Seiyaku Co., Ltd.
Patent: US4460596 A1, 1984 ;
反应条件
1: aq. NaHCO3 / ethyl acetate / Ambient temperature
2: 1.) NaH / 1.) DMF, -50 - -40 deg C, 15 min, 2.) DMF, from -50 to 0 deg C, 30 min
3: 86 percent / POCl3 / dimethylformamide / 8 h / 20 - 25 °C
4: 89 percent / aq. KOH / methanol / 24 h / Ambient temperature
View Scheme
参考文献
Moriya; Takabe; Maeda; Matsumoto; Takashima; Takeyama
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 333 - 341
反应条件
1: 1.) NaH / 1.) DMF, -50 - -40 deg C, 15 min, 2.) DMF, from -50 to 0 deg C, 30 min
2: 86 percent / POCl3 / dimethylformamide / 8 h / 20 - 25 °C
3: 89 percent / aq. KOH / methanol / 24 h / Ambient temperature
View Scheme
参考文献
Moriya; Takabe; Maeda; Matsumoto; Takashima; Takeyama
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 333 - 341
反应条件
1: aq. NaHCO3 / ethyl acetate / Ambient temperature
2: 1.) NaH / 1.) DMF, -50 - -40 deg C, 15 min, 2.) DMF, from -50 to 0 deg C, 30 min
3: 86 percent / POCl3 / dimethylformamide / 8 h / 20 - 25 °C
4: 89 percent / aq. KOH / methanol / 24 h / Ambient temperature
View Scheme
参考文献
Moriya; Takabe; Maeda; Matsumoto; Takashima; Takeyama
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 333 - 341
反应条件
1: 86 percent / POCl3 / dimethylformamide / 8 h / 20 - 25 °C
2: 89 percent / aq. KOH / methanol / 24 h / Ambient temperature
View Scheme
参考文献
Moriya; Takabe; Maeda; Matsumoto; Takashima; Takeyama
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 333 - 341
