Drewe, William C.; Nanjunda, Rupesh; Gunaratnam, Mekala; Beltran, Monica; Parkinson, Gary N.; Reszka, Anthony P.; Wilson, W. David; Neidle, Stephen
Journal of Medicinal Chemistry, 2008 , vol. 51, # 24 p. 7751 - 7767
1: 4-nitro-aniline; 3-chloropropanoyl chloride With triethylamine in tetrahydrofuran
T=20°C; 2.3 h; Cooling with ice;
2: pyrrolidine in tetrahydrofuran
T=20°C; 14 h; Cooling with ice;
参考文献
Lombardo, Caterina M.; Welsh, Sarah J.; Strauss, Sandra J.; Dale, Aaron G.; Todd, Alan K.; Nanjunda, Rupesh; Wilson, W. David; Neidle, Stephen
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 18 p. 5984 - 5988
Moore, Michael J. B.; Schultes, Christoph M.; Cuesta, Javier; Cuenca, Francisco; Gunaratnam, Mekala; Tanious, Farial A.; Wilson, W. David; Neidle, Stephen
Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 582 - 599
1: 97 percent / 16 h / 50 °C
2: 71 percent / methanol / 0 - 20 °C
View Scheme
参考文献
Moorhouse, Adam D.; Santos, Ana Mafalda; Gunaratnam, Mekala; Moore, Michael; Neidle, Stephen; Moses, John E.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15972 - 15973
Moore, Michael J. B.; Schultes, Christoph M.; Cuesta, Javier; Cuenca, Francisco; Gunaratnam, Mekala; Tanious, Farial A.; Wilson, W. David; Neidle, Stephen
Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 582 - 599
