5-甲基-3,6-二氧代-2,3,6,7-四氢-呋喃并[2,3-f]吲哚合成路线 （共 6 条）
反应条件
aluminium trichloride
T=180°C;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2005/41957 A1, 2005 ;
Location in patent: Page/Page column 15 ;
WO 2005/041957 A1
反应条件
1: 94 percent / pyridine / CH2Cl2 / 0 °C
2: 76 percent / AlCl3 / 180 °C
View Scheme
参考文献
Chambers, Robert J.; Abrams, Kristin; Garceau, Norman Y.; Kamath, Ajith V.; Manley, Christopher M.; Lilley, Susan C.; Otte, Douglas A.; Scott, Dennis O.; Sheils, Alissa L.; Tess, David A.; Vellekoop, A. Samuel; Zhang, Yan; Lam, Kelvin T.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 307 - 310
反应条件
1: 83 percent / TEA; DMAP / dimethylformamide / 0 °C
2: 89 percent / AlCl3 / 180 °C
3: 94 percent / pyridine / CH2Cl2 / 0 °C
4: 76 percent / AlCl3 / 180 °C
View Scheme
参考文献
Chambers, Robert J.; Abrams, Kristin; Garceau, Norman Y.; Kamath, Ajith V.; Manley, Christopher M.; Lilley, Susan C.; Otte, Douglas A.; Scott, Dennis O.; Sheils, Alissa L.; Tess, David A.; Vellekoop, A. Samuel; Zhang, Yan; Lam, Kelvin T.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 307 - 310
反应条件
1: 89 percent / AlCl3 / 180 °C
2: 94 percent / pyridine / CH2Cl2 / 0 °C
3: 76 percent / AlCl3 / 180 °C
View Scheme
参考文献
Chambers, Robert J.; Abrams, Kristin; Garceau, Norman Y.; Kamath, Ajith V.; Manley, Christopher M.; Lilley, Susan C.; Otte, Douglas A.; Scott, Dennis O.; Sheils, Alissa L.; Tess, David A.; Vellekoop, A. Samuel; Zhang, Yan; Lam, Kelvin T.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 307 - 310
反应条件
sodium tetrahydroborate in methanol
T=0°C;
参考文献
Chambers, Robert J.; Abrams, Kristin; Garceau, Norman Y.; Kamath, Ajith V.; Manley, Christopher M.; Lilley, Susan C.; Otte, Douglas A.; Scott, Dennis O.; Sheils, Alissa L.; Tess, David A.; Vellekoop, A. Samuel; Zhang, Yan; Lam, Kelvin T.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 307 - 310
反应条件
1: 92 percent / NaBH4 / methanol / 0 °C
2: 88 percent / TFA / acetonitrile / 20 °C
View Scheme
参考文献
Chambers, Robert J.; Abrams, Kristin; Garceau, Norman Y.; Kamath, Ajith V.; Manley, Christopher M.; Lilley, Susan C.; Otte, Douglas A.; Scott, Dennis O.; Sheils, Alissa L.; Tess, David A.; Vellekoop, A. Samuel; Zhang, Yan; Lam, Kelvin T.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 307 - 310
