5-甲基-6-氧代-6,7-二氢-呋喃并[2,3-f]吲哚合成路线 （共 6 条）
反应条件
trifluoroacetic acid in acetonitrile
T=20°C;
参考文献
Chambers, Robert J.; Abrams, Kristin; Garceau, Norman Y.; Kamath, Ajith V.; Manley, Christopher M.; Lilley, Susan C.; Otte, Douglas A.; Scott, Dennis O.; Sheils, Alissa L.; Tess, David A.; Vellekoop, A. Samuel; Zhang, Yan; Lam, Kelvin T.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 307 - 310
反应条件
1: 92 percent / NaBH4 / methanol / 0 °C
2: 88 percent / TFA / acetonitrile / 20 °C
View Scheme
参考文献
Chambers, Robert J.; Abrams, Kristin; Garceau, Norman Y.; Kamath, Ajith V.; Manley, Christopher M.; Lilley, Susan C.; Otte, Douglas A.; Scott, Dennis O.; Sheils, Alissa L.; Tess, David A.; Vellekoop, A. Samuel; Zhang, Yan; Lam, Kelvin T.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 307 - 310
反应条件
1: 76 percent / AlCl3 / 180 °C
2: 92 percent / NaBH4 / methanol / 0 °C
3: 88 percent / TFA / acetonitrile / 20 °C
View Scheme
参考文献
Chambers, Robert J.; Abrams, Kristin; Garceau, Norman Y.; Kamath, Ajith V.; Manley, Christopher M.; Lilley, Susan C.; Otte, Douglas A.; Scott, Dennis O.; Sheils, Alissa L.; Tess, David A.; Vellekoop, A. Samuel; Zhang, Yan; Lam, Kelvin T.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 307 - 310
反应条件
1: 94 percent / pyridine / CH2Cl2 / 0 °C
2: 76 percent / AlCl3 / 180 °C
3: 92 percent / NaBH4 / methanol / 0 °C
4: 88 percent / TFA / acetonitrile / 20 °C
View Scheme
参考文献
Chambers, Robert J.; Abrams, Kristin; Garceau, Norman Y.; Kamath, Ajith V.; Manley, Christopher M.; Lilley, Susan C.; Otte, Douglas A.; Scott, Dennis O.; Sheils, Alissa L.; Tess, David A.; Vellekoop, A. Samuel; Zhang, Yan; Lam, Kelvin T.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 307 - 310
反应条件
1: 83 percent / TEA; DMAP / dimethylformamide / 0 °C
2: 89 percent / AlCl3 / 180 °C
3: 94 percent / pyridine / CH2Cl2 / 0 °C
4: 76 percent / AlCl3 / 180 °C
5: 92 percent / NaBH4 / methanol / 0 °C
6: 88 percent / TFA / acetonitrile / 20 °C
View Scheme
参考文献
Chambers, Robert J.; Abrams, Kristin; Garceau, Norman Y.; Kamath, Ajith V.; Manley, Christopher M.; Lilley, Susan C.; Otte, Douglas A.; Scott, Dennis O.; Sheils, Alissa L.; Tess, David A.; Vellekoop, A. Samuel; Zhang, Yan; Lam, Kelvin T.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 307 - 310
反应条件
1: 89 percent / AlCl3 / 180 °C
2: 94 percent / pyridine / CH2Cl2 / 0 °C
3: 76 percent / AlCl3 / 180 °C
4: 92 percent / NaBH4 / methanol / 0 °C
5: 88 percent / TFA / acetonitrile / 20 °C
View Scheme
参考文献
Chambers, Robert J.; Abrams, Kristin; Garceau, Norman Y.; Kamath, Ajith V.; Manley, Christopher M.; Lilley, Susan C.; Otte, Douglas A.; Scott, Dennis O.; Sheils, Alissa L.; Tess, David A.; Vellekoop, A. Samuel; Zhang, Yan; Lam, Kelvin T.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 307 - 310
