3-(3-氯丙基)-7,8-二甲氧基-2,3,4,5-四氢-1H-3-苯并氮杂卓-2-酮合成路线 (共 4 条)
反应条件
1: With potassium carbonate; sodium iodide in acetone T=20 - 65°C; 2: With triethylamine; acetyl chloride in toluene 3: With hydrogenchloride in water; toluene pH=2 - 3; Product distribution / selectivity;
参考文献
Alembic Pharmaceuticals Limited
Patent: EP2495237 A1, 2012 ;
Location in patent: Page/Page column 8 ;
反应条件
hydrogen; acetic acid; palladium on activated charcoal
T=50°C; P=3750.3 Torr; 6 h;
参考文献
Bomhard, Andreas; Reiffen, Manfred; Heider, Joachim; Psiorz, Manfred; Lillie, Christian
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 942 - 947
参考文献
Dr. Karl Thomae Gesellschaft mit beschrankter Haftung
Patent: US4490369 A1, 1984 ;
反应条件
in dimethyl sulfoxide; acetone
参考文献
Dr. Karl Thomae Gesellschaft mit beschrankter Haftung
Patent: US4490369 A1, 1984 ;