2,4,5,6-四氢环戊烯并[c]吡唑-3-甲酰胺合成路线 （共 4 条）
反应条件
ammonia in methanol T=95°C; 20 h; Product distribution / selectivity;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2006/52569 A1, 2006 ;
Location in patent: Page/Page column 79 ;
反应条件
1,1'-carbonyldiimidazole in tetrahydrofuran T=20 - 60°C; 1 h;
参考文献
Wilson, Robert D.; Cleator, Ed; Ashwood, Michael S.; Bio, Matthew M.; Brands, Karel M.J.; Davies, Antony J.; Dolling, Ulf-H; Emerson, Khateeta M.; Gibb, Andrew D.; Hands, David; McKeown, Arlene E.; Oliver, Steven F.; Reamer, Robert A.; Sheen, Faye J.; Stewart, Gavin W.; Zhou, George X.
Organic Process Research and Development, 2009 , vol. 13, # 3 p. 543 - 547
反应条件
triethylamine; trifluoroacetic anhydride T=-10 - -5°C;
参考文献
Wilson, Robert D.; Cleator, Ed; Ashwood, Michael S.; Bio, Matthew M.; Brands, Karel M.J.; Davies, Antony J.; Dolling, Ulf-H; Emerson, Khateeta M.; Gibb, Andrew D.; Hands, David; McKeown, Arlene E.; Oliver, Steven F.; Reamer, Robert A.; Sheen, Faye J.; Stewart, Gavin W.; Zhou, George X.
Organic Process Research and Development, 2009 , vol. 13, # 3 p. 543 - 547
反应条件
1: With sodium chloride T=80°C; 0.25 h; 2: With trichlorophosphate T=80°C;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2006/52569 A1, 2006 ;
Location in patent: Page/Page column 75 ;
