(3beta)-17-(1H-苯并咪唑-1-基)雄甾-5,16-二烯-3-醇 3-乙酸酯合成路线 （共 4 条）
反应条件
potassium hydroxide in methanol T=20°C; 1.5 h;
参考文献
UNIVERSITY OF MARYLAND
Patent: WO2006/93993 A1, 2006 ;
Location in patent: Page/Page column 27; 28; 44 ;
WO 2006/093993 A1
反应条件
palladium 10 on activated carbon in benzonitrile
Reflux;
参考文献
UNIVERSITY OF MARYLAND, BALTIMORE
Patent: WO2009/120565 A2, 2009 ;
Location in patent: Page/Page column 10; 34 ;
WO 2009/120565 A2
反应条件
1: 88.7 percent / K2CO3 / dimethylformamide / 1.5 h / 80 °C
2: 73.8 percent / Pd/C; benzonitrile / 5 h / Heating
View Scheme
参考文献
Handratta, Venkatesh D.; Vasaitis, Tadas S.; Njar, Vincent C. O.; Gediya, Lalji K.; Kataria, Ritesh; Chopra, Pankaj; Newman Jr., Donnell; Farquhar, Rena; Guo, Zhiyong; Qiu, Yun; Brodie, Angela M. H.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 8 p. 2972 - 2984
反应条件
1: 88.7 percent / K2CO3 / dimethylformamide / 1.5 h / 80 °C
2: 73.8 percent / Pd/C; benzonitrile / 5 h / Heating
View Scheme
参考文献
Handratta, Venkatesh D.; Vasaitis, Tadas S.; Njar, Vincent C. O.; Gediya, Lalji K.; Kataria, Ritesh; Chopra, Pankaj; Newman Jr., Donnell; Farquhar, Rena; Guo, Zhiyong; Qiu, Yun; Brodie, Angela M. H.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 8 p. 2972 - 2984
