7-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)喹啉合成路线 （共 3 条）
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane
T=80°C;
参考文献
PFIZER INC.; BROWN, Matthew Frank; CHE, Ye; MARFAT, Anthony; MELNICK, Michael Joseph; MONTGOMERY, Justin Ian; REILLY, Usa
Patent: WO2011/73845 A1, 2011 ;
Location in patent: Page/Page column 87 ;
WO 2011/073845 A1
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in dimethyl sulfoxide
T=20 - 80°C; Inert atmosphere;
参考文献
PROGENICS PHARMACEUTICALS, INC.
Patent: WO2009/155527 A2, 2009 ;
Location in patent: Page/Page column 135 ;
WO 2009/155527 A2
反应条件
1: pyridine / dichloromethane / 0 - 25 °C
2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / 80 °C
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参考文献
PFIZER INC.; BROWN, Matthew Frank; CHE, Ye; MARFAT, Anthony; MELNICK, Michael Joseph; MONTGOMERY, Justin Ian; REILLY, Usa
Patent: WO2011/73845 A1, 2011 ;
WO 2011/073845 A1
