ammonium acetate in acetic acid T=130 - 140°C; 2 h;

1: 1.) NaH / 1.) DMF, -50 - -40 deg C, 15 min, 2.) DMF, from -50 to 0 deg C, 30 min 2: 86 percent / POCl3 / dimethylformamide / 8 h / 20 - 25 °C 3: 89 percent / aq. KOH / methanol / 24 h / Ambient temperature View Scheme