1: (3R)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid With N,O-bis-(trimethylsilyl)-acetamide in acetonitrile 1.5 h; Heating / reflux; 2: (4'-chlorosulfonyl-biphenyl-4-yl)carbamic acid isopropylester in acetonitrile 2.5 h; Heating / reflux;