1: With sodium tetrahydroborate; boron trifluoride diethyl etherate in tetrahydrofuran; diethyl ether T=20°C; 0.5 h; Inert atmosphere; 2: 5-phenylisoxazole-3-(N-methyl)carboxamide in tetrahydrofuran; diethyl ether 4 h; Reflux; Further stages;

1.1: ethanol; water / 168 h / 20 °C 1.2: 5 h / Reflux 2.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C / Inert atmosphere 2.2: 4 h / Reflux View Scheme