3,4-二氯-2-羟基-3-噁-2h-1,4-苯并噁嗪-7-羧酸乙酯合成路线 （共 4 条）
反应条件
sodium hydrogencarbonate
1 h; Heating;
参考文献
UNIVERSITY OF LJUBLJANA; LEK PHARMACEUTICALS d.d.
Patent: WO2005/51934 A1, 2005 ;
Location in patent: Page/Page column 44; 46 ;
反应条件
1: 96 percent / sulphuric acid / 2 h / Heating
2: 100 percent / H2 / Pd/C / ethanol / 20 °C
3: 60 percent / triethylamine / diethyl ether / 5 h / -10 - 20 °C
4: 83 percent / aq. NaHCO3 / 1 h / Heating
View Scheme
参考文献
Anderluh, Petra Stefanic; Anderluh, Marko; Ilas, Janez; Mravljak, Janez; Dolenc, Marija Sollner; Stegnar, Mojca; Kikelj, Danijel
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3110 - 3113
反应条件
1: 100 percent / H2 / Pd/C / ethanol / 20 °C
2: 60 percent / triethylamine / diethyl ether / 5 h / -10 - 20 °C
3: 83 percent / aq. NaHCO3 / 1 h / Heating
View Scheme
参考文献
Anderluh, Petra Stefanic; Anderluh, Marko; Ilas, Janez; Mravljak, Janez; Dolenc, Marija Sollner; Stegnar, Mojca; Kikelj, Danijel
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3110 - 3113
反应条件
1: 60 percent / triethylamine / diethyl ether / 5 h / -10 - 20 °C
2: 83 percent / aq. NaHCO3 / 1 h / Heating
View Scheme
参考文献
Anderluh, Petra Stefanic; Anderluh, Marko; Ilas, Janez; Mravljak, Janez; Dolenc, Marija Sollner; Stegnar, Mojca; Kikelj, Danijel
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3110 - 3113
