5-酮-4,5-二氢-1H-吡唑-3-羧酸乙酯合成路线 （共 5 条）
反应条件
1: diethyl oxalacetate sodium salt in benzene 0.333333 h; 2: With acetic acid 0.5 h; 3: hydrazine monohydrochloride T=100°C; 24.5 h; Heating / reflux;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2004/74257 A1, 2004 ;
Location in patent: Page 26; 37; 38 ;
WO 2004/074257 A1
反应条件
hydrazine monohydrochloride; acetic acid in water; benzene 3 h; Heating;
参考文献
Ochi; Miyasaka
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 4 p. 1228 - 1234
反应条件
hydrazine monohydrochloride 24 h; Heating;
参考文献
Martins, Marcos A. P.; Pereira, Claudio M. P.; Zimmermann, Nilo E. K.; Moura, Sidnei; Sinhorin, Adilson P.; Cunico, Wilson; Zanatta, Nilo; Bonacorso, Helio G.; Flores, Alex C. F.
Synthesis, 2003 , # 15 p. 2353 - 2357
反应条件
hydrazine monohydrochloride 24 h; Heating;
参考文献
Martins, Marcos A. P.; Pereira, Claudio M. P.; Zimmermann, Nilo E. K.; Moura, Sidnei; Sinhorin, Adilson P.; Cunico, Wilson; Zanatta, Nilo; Bonacorso, Helio G.; Flores, Alex C. F.
Synthesis, 2003 , # 15 p. 2353 - 2357
反应条件
potassium carbonate in acetonitrile 16 h; Heating;
参考文献
Wyeth
Patent: US2006/276445 A1, 2006 ;
Location in patent: Page/Page column 42 ;
