4-羟基-1-(2,4-二甲基苯基)吡唑并[3,4-d]嘧啶合成路线 (共 3 条)
反应条件
POCl2 in 1,2-dichloro-ethane T=0°C;
参考文献
ARROW THERAPEUTICS LIMITED
Patent: WO2005/47288 A1, 2005 ;
Location in patent: Page/Page column 23-24 ;
WO 2005/047288 A1
反应条件
in formamide
T=150°C; 48 h;
参考文献
ARROW THERAPEUTICS LIMITED
Patent: WO2005/47288 A1, 2005 ;
Location in patent: Page/Page column 23-24 ;
WO 2005/047288 A1
反应条件
T=200°C; 0.333333 h; Microwave irradiation;
参考文献
Niswender, Colleen M.; Lebois, Evan P.; Luo, Qingwei; Kim, Kwangho; Muchalski, Hubert; Yin, Huiyong; Conn, P. Jeffrey; Lindsley, Craig W.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5626 - 5630