4-氯-1-(2-氯苯基)-1H-吡唑并[3,4-d]嘧啶合成路线 （共 6 条）
反应条件
trichlorophosphate
12 h; Reflux;
参考文献
Bonn, Peter; Brink, D. Mikael; Faegerhag, Jonas; Jurva, Ulrik; Robb, Graeme R.; Schnecke, Volker; Svensson Henriksson, Anette; Waring, Michael J.; Westerlund, Christer
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7302 - 7305
反应条件
in 1,4-dioxane
T=200°C; 0.666667 h; Sealed tube;
参考文献
Babu, Suresh; Morrill, Christie; Almstead, Neil G.; Moon, Young-Choon
Organic Letters, 2013 , vol. 15, # 8 p. 1882 - 1885
反应条件
1: N,N-dimethyl-formamide / 1 h / 20 °C / |Inert atmosphere
2: 1,4-dioxane / 0.67 h / 200 °C / |Sealed tube
View Scheme
参考文献
Babu, Suresh; Morrill, Christie; Almstead, Neil G.; Moon, Young-Choon
Organic Letters, 2013 , vol. 15, # 8 p. 1882 - 1885
反应条件
1: ethanol / 1 h / |Reflux
2: sulfuric acid / 0.5 h / 20 °C
3: 0.5 h / 210 °C / |Microwave irradiation
4: trichlorophosphate / 12 h / |Reflux
View Scheme
参考文献
Bonn, Peter; Brink, D. Mikael; Faegerhag, Jonas; Jurva, Ulrik; Robb, Graeme R.; Schnecke, Volker; Svensson Henriksson, Anette; Waring, Michael J.; Westerlund, Christer
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7302 - 7305
反应条件
1: sulfuric acid / 0.5 h / 20 °C
2: 0.5 h / 210 °C / |Microwave irradiation
3: trichlorophosphate / 12 h / |Reflux
View Scheme
参考文献
Bonn, Peter; Brink, D. Mikael; Faegerhag, Jonas; Jurva, Ulrik; Robb, Graeme R.; Schnecke, Volker; Svensson Henriksson, Anette; Waring, Michael J.; Westerlund, Christer
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7302 - 7305
反应条件
1: 0.5 h / 210 °C / |Microwave irradiation
2: trichlorophosphate / 12 h / |Reflux
View Scheme
参考文献
Bonn, Peter; Brink, D. Mikael; Faegerhag, Jonas; Jurva, Ulrik; Robb, Graeme R.; Schnecke, Volker; Svensson Henriksson, Anette; Waring, Michael J.; Westerlund, Christer
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7302 - 7305
