zinc T=20°C;

1: With sodium carbonate; Pd(Ph3P)4 in ethylene glycol dimethyl ether Suzuki cross-coupling reaction; 48 h; Heating; 2: in tetrahydrofuran 1 h;

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.75 h / -78 °C 1.2: 56 percent / hexane; tetrahydrofuran / -78 - 20 °C 2.1: aq. Na2CO3 / tetrakis(triphenylphosphino)palladium / 1,2-dimethoxy-ethane / 48 h / Heating 2.2: 99 percent / tetrahydrofuran / 1 h View Scheme