alpha-溴-2-氯苯乙酸甲酯合成路线 （共 22 条）
反应条件
sulfuric acid 3 h; Reflux;
参考文献
Reddy, K. Tatendra; Kumar, K. Suneel; Omprakash; Dubey
Synthetic Communications, 2013 , vol. 43, # 10 p. 1387 - 1396
反应条件
N-bromosuccinmide; dibenzoyl peroxide in 1,2-dichloro-ethane 12 h; Sealed tubeReflux;
参考文献
Sun, Xiuyun; Shan, Gang; Sun, Yonghui; Rao, Yu
Angewandte Chemie - International Edition, 2013 , vol. 52, # 16 p. 4440 - 4444
Angew. Chem., 2013 , vol. 125, # 16 p. 4536 - 4540,5
反应条件
1: H2SO4 / Heating 2: NBS, AIBN / CCl4 / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 23 p. 3738 - 3742
反应条件
thionyl chloride; bromine in hexane
参考文献
Merck and Co., Inc.
Patent: US5246944 A1, 1993 ;
US 5246944 A
反应条件
in methanol; toluene 0.25 h; Inert atmosphereCooling in water bath;
参考文献
CERENIS THERAPEUTICS SA; ONICIU, Daniela Carmen; DASSEUX, Jean-Louis Henri; BARBARAS, Ronald; KOCHUBEY, Valery; KOVALSKY, Dmitry; RODIN, Oleg Gennadievich; GEOFFROY, Otto; RZEPIELA, Anna
Patent: WO2012/54535 A2, 2012 ;
Location in patent: Page/Page column 180 ;
反应条件
thionyl bromide in toluene T=20°C; Bromination;
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 5 p. 900 - 910
反应条件
1: H2SO4 / Heating 2: SOBr2 / toluene / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 5 p. 900 - 910
反应条件
1: aq. KOH; LiCl / dioxane / 10 - 15 °C 2: H2SO4 / Heating 3: SOBr2 / toluene / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 5 p. 900 - 910
反应条件
1: N-chloro-succinimide; palladium diacetate; sodium peroxodisulphate; trifluorormethanesulfonic acid / 1,2-dichloro-ethane / 2 h / 60 °C / |Sealed tube 2: N-bromosuccinmide; dibenzoyl peroxide / 1,2-dichloro-ethane / 12 h / |Sealed tube; |Reflux View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 16 p. 4440 - 4444
Angew. Chem., , vol. 125, # 16 p. 4536 - 4540,5
反应条件
1: Br2 / 16 h / 70 °C 2: 13.2 g View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 30, # 10 p. 3601 - 3616
