alpha-溴-2-氯苯乙酸甲酯合成路线 （共 22 条）
参考文献
Sohda; Mizuno; Imamiya; Tawada; Meguro; Kawamatsu; Yamamoto
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3601 - 3616
反应条件
1.1: sodium carbonate / methanol / 1 h / 60 - 65 °C 1.2: 24 h / 60 - 65 °C 2.1: dichloromethane; ethyl acetate / 6 h / 20 - 45 °C 3.1: potassium carbonate / dichloromethane; water / 0.67 h / 10 °C View Scheme
参考文献
DONG WHA PHARM. CO., LTD.; OH, Yoon Seok; SHIN, Dong Hyuk; JUNG, Jin Yong
Patent: WO2011/83955 A2, 2011 ;
反应条件
1: 2-(2-aminoethyl)-thiophene; formaldehyd in 1,2-dichloro-ethane 4 h; Heating / reflux; 2: With hydrogenchloride in 1,2-dichloro-ethane; N,N-dimethyl-formamide T=30 - 70°C; 4 h; 3: 2-chloro-α-methoxycarbonylbenzyl bromide With sulfuric acid; sodium carbonate Product distribution / selectivity; more than 3 stages;
参考文献
IPCA Laboratories Limited
Patent: EP1772455 A2, 2007 ;
Location in patent: Page/Page column 10 ;
反应条件
1: With potassium carbonate in acetone 2: With sulfuric acid
参考文献
Valeriano, Merli; Daverio, Paola; Bianchi, Stefano
Patent: US2004/24011 A1, 2004 ;
Location in patent: Page 7 ;
反应条件
1.1: potassium carbonate / methanol; water / 0.17 h / 25 °C 1.2: 6 h / 60 - 65 °C 2.1: hydrogenchloride / water; acetone / 25 °C View Scheme
参考文献
Reddy, K. Tatendra; Kumar, K. Suneel; Omprakash; Dubey
Synthetic Communications, 2013 , vol. 43, # 10 p. 1387 - 1396
反应条件
1: 2-chloro-α-methoxycarbonylbenzyl bromide With potassium carbonate in methanol; water T=25°C; 0.166667 h; 2: 4,5,6,7-tetrahydro-thieno[2,3-c]pyridine in methanol; water T=60 - 65°C; 6 h;
参考文献
Reddy, K. Tatendra; Kumar, K. Suneel; Omprakash; Dubey
Synthetic Communications, 2013 , vol. 43, # 10 p. 1387 - 1396
反应条件
1: sodium hydrogencarbonate / methanol / 10 °C / |Reflux 2: hydrogenchloride / water / 25 - 55 °C View Scheme
参考文献
Reddy, K. Tatendra; Kumar, K. Suneel; Omprakash; Dubey
Synthetic Communications, 2013 , vol. 43, # 10 p. 1387 - 1396
反应条件
1.1: sodium carbonate / methanol / 1 h / 60 - 65 °C 1.2: 24 h / 60 - 65 °C 2.1: dichloromethane; ethyl acetate / 6 h / 20 - 45 °C 3.1: potassium carbonate / dichloromethane; water / 0.67 h / 10 °C 4.1: sulfuric acid / water; Sec-butyl alcohol / 0.5 h / 20 - 25 °C View Scheme
参考文献
DONG WHA PHARM. CO., LTD.; OH, Yoon Seok; SHIN, Dong Hyuk; JUNG, Jin Yong
Patent: WO2011/83955 A2, 2011 ;
反应条件
triethylamine in N,N-dimethyl-formamide
T=15 - 20°C; 0.5 h;
参考文献
IND-SWIFT LABORATORIES LIMITED
Patent: WO2007/125544 A2, 2007 ;
Location in patent: Page/Page column 14-15 ;
反应条件
triethylamine in 1,2-dichloro-ethane
T=25°C; 5 h; Heating / reflux; Product distribution / selectivity;
参考文献
BATTULA, Srinivasa Reddy
Patent: EP1980563 A1, 2008 ;
Location in patent: Page/Page column 10-11 ;
