2-((2-(二甲基氨基)乙基)硫代)-3-苯基喹啉合成路线 （共 3 条）
反应条件
1: 1.) thiourea, 2.) 1 M aq. NaOH / 1.) ethanol, reflux, 1 h, 2.) reflux, 2 h
2: 1.) NaH / 1.) DMF, RT, 0.5 h, 2.) DMF, RT, 20 h
View Scheme
参考文献
Blackburn, Thomas P.; Cox, Barry; Guildford, Allen J.; Count, David J. Le; Middlemiss, Derek N.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2252 - 2259
反应条件
sodium hydride
1.) DMF, RT, 1 h, 2.) DMF, 75 deg C, 5 h; Multistep reaction;
参考文献
Blackburn, Thomas P.; Cox, Barry; Guildford, Allen J.; Count, David J. Le; Middlemiss, Derek N.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2252 - 2259
反应条件
sodium hydride
1.) DMF, RT, 0.5 h, 2.) DMF, RT, 20 h; Multistep reaction;
参考文献
Blackburn, Thomas P.; Cox, Barry; Guildford, Allen J.; Count, David J. Le; Middlemiss, Derek N.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2252 - 2259
