1: 1.) LDA / 1.) THF, -78 deg C, 1h, 2.) THF, overnight 2: 1.) sodium tert-butoxide / 1.) THF, 15 min, 2.) THF, 30 min 3: trifluoroacetic acid / 1 h / Ambient temperature 4: 2M aq. NaOH / tetrahydrofuran / 0.25 h / Ambient temperature 5: 74 percent / 1M Dibal / hexane; CH2Cl2 / 1 h / Ambient temperature 6: 41 percent / triphenylphosphine, diethyl azodiacrboxylate / tetrahydrofuran 7: 1.) hydrazine hydrate, 2.) 18percent aq.HCl / 1.) methanol, reflux, 3 h, 2.) methanol, reflux, 30 min View Scheme

1: 74 percent / 1M Dibal / hexane; CH2Cl2 / 1 h / Ambient temperature 2: 41 percent / triphenylphosphine, diethyl azodiacrboxylate / tetrahydrofuran 3: 1.) hydrazine hydrate, 2.) 18percent aq.HCl / 1.) methanol, reflux, 3 h, 2.) methanol, reflux, 30 min View Scheme

1: 1.) sodium tert-butoxide / 1.) THF, 15 min, 2.) THF, 30 min 2: trifluoroacetic acid / 1 h / Ambient temperature 3: 2M aq. NaOH / tetrahydrofuran / 0.25 h / Ambient temperature 4: 74 percent / 1M Dibal / hexane; CH2Cl2 / 1 h / Ambient temperature 5: 41 percent / triphenylphosphine, diethyl azodiacrboxylate / tetrahydrofuran 6: 1.) hydrazine hydrate, 2.) 18percent aq.HCl / 1.) methanol, reflux, 3 h, 2.) methanol, reflux, 30 min View Scheme

1: trifluoroacetic acid / 1 h / Ambient temperature 2: 2M aq. NaOH / tetrahydrofuran / 0.25 h / Ambient temperature 3: 74 percent / 1M Dibal / hexane; CH2Cl2 / 1 h / Ambient temperature 4: 41 percent / triphenylphosphine, diethyl azodiacrboxylate / tetrahydrofuran 5: 1.) hydrazine hydrate, 2.) 18percent aq.HCl / 1.) methanol, reflux, 3 h, 2.) methanol, reflux, 30 min View Scheme

1: 41 percent / triphenylphosphine, diethyl azodiacrboxylate / tetrahydrofuran 2: 1.) hydrazine hydrate, 2.) 18percent aq.HCl / 1.) methanol, reflux, 3 h, 2.) methanol, reflux, 30 min View Scheme

hydrogenchloride; hydrazine hydrate 1.) methanol, reflux, 3 h, 2.) methanol, reflux, 30 min; Yield given. Multistep reaction;