1-甲基吡唑-4-羧酸乙酯合成路线 （共 9 条）
反应条件
sodium hydroxide in ethanol; water
参考文献
Monsanto Company
Patent: US5498630 A1, 1996 ;
反应条件
2: 28percent aq. NH4OH / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 28, # 8 p. 1849 - 1852
反应条件
in ethanol
T=5 - 20°C; Time;
参考文献
ARRAY BIOPHARMA INC.; ANDREWS, Steven Wade; BLAKE, James F.; BRANDHUBER, Barbara J.; KERCHER, Timothy; WINSKI, Shannon L.
Patent: WO2014/78325 A1, 2014 ;
Location in patent: Paragraph 00663 ;
反应条件
1: 1H-pyrazole-4-carboxylic acid ethyl ester With sodium hydride in tetrahydrofuran
T=0 - 25°C; 0.75 - 1 h;
2: methyl iodide in tetrahydrofuran
T=25°C; 18 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2003/106459 A1, 2003 ;
Location in patent: Page 115; 156 ;
参考文献
Dunten, Peter W.; Foley, Louise H.; Huby, Nicholas J.S.; Pietranico-Cole, Sherrie L.; Yun, Weiya
Patent: US2004/14766 A1, 2004 ;
反应条件
in 5-amino-1-methyl-1H-pyrazole-4-carboxylic acid,ethyl ester; N,N-dimethyl-formamide
参考文献
Monsanto Company
Patent: US5498630 A1, 1996 ;
反应条件
hydrogenchloride; sodium nitrite; copper(l) chloride
1) < 10 deg C, 10 min, 2) room temp., 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Yamamoto, Susumu; Morimoto, Katsushi; Sato, Toshiaki
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 6 p. 1545 - 1547
反应条件
sulfuric acid; copper; acetic acid; sodium nitrite
1.) from 0 deg C to 5 deg C, 30 min, 2.) from 0 deg C to RT, 30 min; Yield given. Multistep reaction;
参考文献
Huppatz
Australian Journal of Chemistry, 1983 , vol. 36, # 1 p. 135 - 147
参考文献
Yamamoto; Sato; Morimoto; Makino
Journal of Heterocyclic Chemistry, 1992 , vol. 28, # 8 p. 1849 - 1852
