1: 95 percent / hydroxylamine hydrochloride; pyridine / ethanol / 72 h / 90 °C 2: 34 percent / DIAD; PPh3 / toluene / 1 h / Heating View Scheme

<b>Multi-step reaction with 4 steps<br /> </b>1.1: toluene-4-sulfonic acid / toluene / 2 h / 65 &deg;C / |Inert atmosphere<br />2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -55 &deg;C / |Inert atmosphere<br />2.2: 4 h / -55 - 0 &deg;C / |Inert atmosphere<br />3.1: hydrogenchloride / methanol; water / 1 h / 20 &deg;C<br />4.1: selenium(IV) oxide / dimethyl sulfoxide / 0.05 h / 25 - 150 &deg;C / |Microwave irradiation<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1.1: sodium methylate / methanol / 3 h / 50 &deg;C<br />2.1: toluene-4-sulfonic acid / toluene / 2 h / 65 &deg;C / |Inert atmosphere<br />3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -55 &deg;C / |Inert atmosphere<br />3.2: 4 h / -55 - 0 &deg;C / |Inert atmosphere<br />4.1: hydrogenchloride / methanol; water / 1 h / 20 &deg;C<br />5.1: selenium(IV) oxide / dimethyl sulfoxide / 0.05 h / 25 - 150 &deg;C / |Microwave irradiation<br /> <br /> &nbsp;