4-氯-5氢-吡咯并[3,2-D]嘧啶-7-甲酸乙酯合成路线 （共 5 条）
反应条件
trichlorophosphate T=105°C; 3.5 h;
参考文献
Bender, John A.; Yang, Zhong; Kadow, John F.; Meanwell, Nicholas A.
Patent: US2005/124623 A1, 2005 ;
Location in patent: Page/Page column 44 ;
反应条件
sulfuryl dichloride in dichloromethane; acetonitrile T=0°C; 0.5 h;
参考文献
Ham, Young Jin; Lee, Duck-Hyung; Choi, Hwan Geun; Hah, Jung-Mi; Sim, Taebo
Tetrahedron Letters, 2010 , vol. 51, # 35 p. 4609 - 4611
反应条件
1: in ethanol Reflux; 2: With trichlorophosphate Reflux; 3: With sodium hydrogencarbonate 2 h;
参考文献
WO2011/25940 A1, ;
Page/Page column 85 ;
WO 2011/025940 A1
反应条件
1: sodium ethanolate / ethanol / |Reflux 2: ethanol / |Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 1 p. 218 - 222
反应条件
lithium hydroxide; water in tetrahydrofuran T=100°C; 24 h;
参考文献
Bender, John A.; Yang, Zhong; Kadow, John F.; Meanwell, Nicholas A.
Patent: US2005/124623 A1, 2005 ;
Location in patent: Page/Page column 44 ;
