4’-(反式-4-丙基环己基)-3,4-二氟联苯合成路线 （共 5 条）
反应条件
sodium hydroxide; palladium diacetate; triphenylphosphine in benzene T=80°C; 62 h;
参考文献
Tetrahedron Letters, , vol. 38, # 3 p. 439 - 442
反应条件
5 palladium on charcoal; potassium carbonate in ethanol; water T=80°C; Suzuki Coupling; 0.5 h;
参考文献
European Journal of Organic Chemistry, , # 20 p. 4345 - 4350
反应条件
potassium fluoride; {palladium-dichloro-(P(C3H7)3)2} in N,N-dimethyl-formamide T=150°C; 20 h;
参考文献
Journal of Organic Chemistry, , vol. 61, # 21 p. 7232 - 7233
反应条件
1: 1.) Mg, 2.) SiCl4 / 1.) THF, 50 deg C, 2 h, 2.) 0 deg C to r.t., 17 h 2: pyridine / 0.5 h / 0 °C 3: 1.) Bu4NF / 1.) Pd(Ph3P)4 / 1.) THF, r.t., 30 min, 2.) toluene, reflux, 3 h View Scheme
参考文献
Chemical Communications, , # 14 p. 1309 - 1310
反应条件
tetrabutyl ammonium fluoride; tetrakis(triphenylphosphine) palladium(0) 1.) THF, r.t., 30 min, 2.) toluene, reflux, 3 h; Yield given. Multistep reaction;
参考文献
Chemical Communications, , # 14 p. 1309 - 1310
