3-(溴甲基)-5-氟苯甲腈合成路线 （共 3 条）
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in acetonitrile
T=70°C; 1.5 h; Inert atmosphere;
参考文献
MERCK SERONO S.A.; QUATTROPANI, Anna; MONTAGNE, Cyril; SAUER, Wolfgang; CROSIGNANI, Stefano; BOMBRUN, Agnes
Patent: WO2010/112461 A1, 2010 ;
Location in patent: Page/Page column 70 ;
反应条件
bromine; triphenylphosphine in acetonitrile
T=85°C; 2 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2077262 A1, 2009 ;
Location in patent: Page/Page column 72 ;
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile
T=25 - 70°C; 1.33333 h; Inert atmosphere;
参考文献
MERCK SERONO S.A.; BOMBRUN, Agnes; QUATTROPANI, Anna; GONZALEZ, Jerome; DORBAIS, Jerome; KNIGHT, Chris; BAKER-GLENN, Charles
Patent: WO2012/4287 A1, 2012 ;
Location in patent: Page/Page column 74 ;
WO 2012/004287 A1
