2-(6-甲氧基-2-甲基吡啶-3-基)乙腈合成路线 （共 2 条）
反应条件
sodium iodide in water; isopropyl alcohol
参考文献
BRISTOL-MYERS SQUIBB PHARMA COMPANY
Patent: WO2005/51954 A2, 2005 ;
Location in patent: Page/Page column 41; 42 ;
WO 2005/051954 A2
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 45 °C
2.1: water; isopropyl alcohol / 4 h / 35 °C
2.2: 6 h / 5 °C
3.1: trifluoroacetic acid / acetonitrile / 7 h / 90 °C
4.1: 4-methyl-morpholine; N-ethyl-N,N-diisopropylamine; trichlorophosphate / acetonitrile / 0 - 25 °C
5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / -5 - 25 °C
View Scheme
参考文献
Broxer, Sevrine; Fitzgerald, Monica A.; Sfouggatakis, Chris; Defreese, Jessica L.; Barlow, Evan; Powers, Gerald L.; Peddicord, Michael; Su, Bao-Ning; Tai-Yuen, Yue; Pathirana, Charles; Sherbine, James P.
Organic Process Research and Development, 2011 , vol. 15, # 2 p. 343 - 352
