2-(4,6-二氯嘧啶-5-基)乙醇合成路线 （共 3 条）
反应条件
1: N-ethyl-N,N-diisopropylamine / ethanol / 5 h / |Reflux 2: sulfuryl dichloride / toluene / 1 h / |Reflux 3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 110 °C View Scheme
参考文献
NERVIANO MEDICAL SCIENCES S.R.L.; BRASCA, Maria Gabriella; BINDI, Simona; CALDARELLI, Marina; NESI, Marcella; ORRENIUS, Sten Christian; PANZERI, Achille
Patent: WO2014/19908 A2, 2014 ;
反应条件
diisobutylaluminium hydride in diethyl ether
T=-78 - 20°C; 3 h;
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2005/51304 A2, 2005 ;
Location in patent: Page/Page column 155-156 ;
WO 2005/051304 A2
反应条件
sodium tetrahydroborate in methanol
T=0°C; 1 h;
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2008/51404 A1, 2008 ;
Location in patent: Page/Page column 113 ;
