N-叔-丁氧羰基-2-氟-5-甲氧基-4-O-甲基-L-酪氨酸甲酯合成路线 （共 7 条）
反应条件
hydrogen; (S,S)-Et-DUPHOS-Rh in methanol; ethyl acetate
P=1551.49 Torr;
参考文献
CTI PET Systems, Inc.
Patent: US2005/137421 A1, 2005 ;
Location in patent: Page/Page column 5 ;
反应条件
1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in acetone
T=20°C; 0.5 h; Molecular sieve;
参考文献
Stenhagen, Ida S. R.; Kirjavainen, Anna K.; Forsback, Sarita J.; Jorgensen, Charlotte G.; Robins, Edward G.; Luthra, Sajinder K.; Solin, Olof; Gouverneur, Veronique
Chemical Communications, 2013 , vol. 49, # 14 p. 1386 - 1388
反应条件
1.1: bis-[(trifluoroacetoxy)iodo]benzene; iodine / dichloromethane / 3.25 h / 0 - 20 °C
2.1: lithium hydroxide hydrate / water; tetrahydrofuran / 2 h / 20 °C
3.1: dichloromethane; methanol / 20 °C
4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium acetate / dimethyl sulfoxide / 17.17 h / 80 °C / |Inert atmosphere
5.1: sodium hydroxide / methanol / 3 h / |Inert atmosphere
5.2: 0.5 h / 0 °C / |Inert atmosphere
6.1: 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) / acetone / 0.5 h / 20 °C / |Molecular sieve
View Scheme
参考文献
Stenhagen, Ida S. R.; Kirjavainen, Anna K.; Forsback, Sarita J.; Jorgensen, Charlotte G.; Robins, Edward G.; Luthra, Sajinder K.; Solin, Olof; Gouverneur, Veronique
Chemical Communications, 2013 , vol. 49, # 14 p. 1386 - 1388
反应条件
1.1: dichloromethane; methanol / 20 °C
2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium acetate / dimethyl sulfoxide / 17.17 h / 80 °C / |Inert atmosphere
3.1: sodium hydroxide / methanol / 3 h / |Inert atmosphere
3.2: 0.5 h / 0 °C / |Inert atmosphere
4.1: 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) / acetone / 0.5 h / 20 °C / |Molecular sieve
View Scheme
参考文献
Stenhagen, Ida S. R.; Kirjavainen, Anna K.; Forsback, Sarita J.; Jorgensen, Charlotte G.; Robins, Edward G.; Luthra, Sajinder K.; Solin, Olof; Gouverneur, Veronique
Chemical Communications, 2013 , vol. 49, # 14 p. 1386 - 1388
反应条件
1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium acetate / dimethyl sulfoxide / 17.17 h / 80 °C / |Inert atmosphere
2.1: sodium hydroxide / methanol / 3 h / |Inert atmosphere
2.2: 0.5 h / 0 °C / |Inert atmosphere
3.1: 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) / acetone / 0.5 h / 20 °C / |Molecular sieve
View Scheme
参考文献
Stenhagen, Ida S. R.; Kirjavainen, Anna K.; Forsback, Sarita J.; Jorgensen, Charlotte G.; Robins, Edward G.; Luthra, Sajinder K.; Solin, Olof; Gouverneur, Veronique
Chemical Communications, 2013 , vol. 49, # 14 p. 1386 - 1388
反应条件
1.1: lithium hydroxide hydrate / water; tetrahydrofuran / 2 h / 20 °C
2.1: dichloromethane; methanol / 20 °C
3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium acetate / dimethyl sulfoxide / 17.17 h / 80 °C / |Inert atmosphere
4.1: sodium hydroxide / methanol / 3 h / |Inert atmosphere
4.2: 0.5 h / 0 °C / |Inert atmosphere
5.1: 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) / acetone / 0.5 h / 20 °C / |Molecular sieve
View Scheme
参考文献
Stenhagen, Ida S. R.; Kirjavainen, Anna K.; Forsback, Sarita J.; Jorgensen, Charlotte G.; Robins, Edward G.; Luthra, Sajinder K.; Solin, Olof; Gouverneur, Veronique
Chemical Communications, 2013 , vol. 49, # 14 p. 1386 - 1388
反应条件
1.1: sodium hydroxide / methanol / 3 h / |Inert atmosphere
1.2: 0.5 h / 0 °C / |Inert atmosphere
2.1: 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) / acetone / 0.5 h / 20 °C / |Molecular sieve
View Scheme
参考文献
Stenhagen, Ida S. R.; Kirjavainen, Anna K.; Forsback, Sarita J.; Jorgensen, Charlotte G.; Robins, Edward G.; Luthra, Sajinder K.; Solin, Olof; Gouverneur, Veronique
Chemical Communications, 2013 , vol. 49, # 14 p. 1386 - 1388
