6-溴-2-氟-3-甲氧基苯甲醛合成路线 （共 2 条）
反应条件
1: 1-bromo-3-fluoro-4-methoxybenzene With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-78 - 0°C; 0.666667 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=-78 - 20°C; 1 h;
参考文献
KYOWA HAKKO KOGYO CO., LTD.
Patent: EP1726584 A1, 2006 ;
Location in patent: Page/Page column 28 ;
反应条件
1: With boron tribromide in dichloromethane
T=-78 - 20°C; Inert atmosphere;
2: With water in dichloromethane
参考文献
ANACOR PHARMACEUTICALS, INC; JARNAGIN, Kurt; AKAMA, Tsutomu
Patent: WO2011/94450 A1, 2011 ;
Location in patent: Page/Page column 149-150 ;
