乙基 2-苯基嘧啶-5-羧酸合成路线 （共 19 条）
反应条件
1: With zinc in tetrahydrofuran T=60°C; 1 h; 2: With acetic acid in tetrahydrofuran T=60°C; 23 h;
参考文献
Lopes, Alexandra Basilio; Miguez, Eduardo; Kuemmerle, Arthur Eugen; Rumjanek, Victor Marcos; Fraga, Carlos Alberto Manssour; Barreiro, Eliezer J.
Molecules, 2013 , vol. 18, # 10 p. 11683 - 11704
反应条件
sodium in ethanol Condensation; cyclization; 1 h; Heating;
参考文献
Signal Pharmaceuticals, Inc.
Patent: US5811428 A1, 1998 ;
反应条件
piperidine; sodium salt of nitromalonic aldehyde in 1,4-dioxane T=20°C; 3 h;
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 29, # 4 p. 432 - 436
Khimiya Geterotsiklicheskikh Soedinenii, , # 4 p. 509 - 513
反应条件
in toluene T=120°C; 24 h;
参考文献
Guzman; Romero; Talamas; Villena; Greenhouse; Muchowski
Journal of Organic Chemistry, 1996 , vol. 61, # 7 p. 2470 - 2483
反应条件
piperidine; sodium salt of nitromalonic aldehyde in 1,4-dioxane; ethanol T=20°C; 3 h;
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 29, # 4 p. 432 - 436
Khimiya Geterotsiklicheskikh Soedinenii, , # 4 p. 509 - 513
反应条件
1: 54 percent / KMnO4 / H2O / 5 h / 100 °C 2: 44 percent / concentrated HCl / 4 h / Heating View Scheme
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , p. 303 - 307
Khimiya Geterotsiklicheskikh Soedinenii, , vol. 24, # 3 p. 371 - 375
反应条件
sodium ethanolate in ethanol 1 h; Heating;
参考文献
Schenone, Pietro; Sansebastiano, Laura; Mosti, Luisa
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 295 - 305
反应条件
1: 91 percent / sodium hydroxide / H2O; tetrahydrofuran / 1 h / 0 °C 2: tetrahydrofuran / Heating; 2-5 h 3: 42 percent / toluene / 24 h / 120 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 7 p. 2470 - 2483
反应条件
hydrogenchloride 1) 5 deg C, 4 h 2) room temperature, 4 days;
参考文献
Mamaev, V. P.; Mikhaleva, M. A.; Shadrina, A. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1988 , p. 303 - 307
Khimiya Geterotsiklicheskikh Soedinenii, 1988 , vol. 24, # 3 p. 371 - 375
反应条件
1.1: sodium / ethanol / 9 h / 20 °C / |Inert atmosphere 2.1: trichlorophosphate / 1 h / 100 °C 3.1: zinc / tetrahydrofuran / 1 h / 60 °C 3.2: 23 h / 60 °C View Scheme
参考文献
Molecules, , vol. 18, # 10 p. 11683 - 11704
