乙基 2-苯基嘧啶-5-羧酸合成路线 （共 19 条）
反应条件
1.1: trichlorophosphate / 1 h / 100 °C 2.1: zinc / tetrahydrofuran / 1 h / 60 °C 2.2: 23 h / 60 °C View Scheme
参考文献
Molecules, , vol. 18, # 10 p. 11683 - 11704
反应条件
1: 10 g / thionylchloride / benzene / 3 h / Heating 2: 85 percent / concentrated NH4OH / H2O / 2 h 3: 92 percent / POCl3 / 4 h / Heating 4: 81 percent / HCl / 1) 5 deg C, 4 h 2) room temperature, 4 days View Scheme
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , p. 303 - 307
Khimiya Geterotsiklicheskikh Soedinenii, , vol. 24, # 3 p. 371 - 375
反应条件
1: 85 percent / concentrated NH4OH / H2O / 2 h 2: 92 percent / POCl3 / 4 h / Heating 3: 81 percent / HCl / 1) 5 deg C, 4 h 2) room temperature, 4 days View Scheme
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , p. 303 - 307
Khimiya Geterotsiklicheskikh Soedinenii, , vol. 24, # 3 p. 371 - 375
反应条件
hydrogenchloride 4 h; Heating;
参考文献
Mamaev, V. P.; Mikhaleva, M. A.; Shadrina, A. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1988 , p. 303 - 307
Khimiya Geterotsiklicheskikh Soedinenii, 1988 , vol. 24, # 3 p. 371 - 375
反应条件
1: tetrahydrofuran / Heating; 2-5 h 2: 42 percent / toluene / 24 h / 120 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 7 p. 2470 - 2483
反应条件
1: 92 percent / POCl3 / 4 h / Heating 2: 81 percent / HCl / 1) 5 deg C, 4 h 2) room temperature, 4 days View Scheme
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , p. 303 - 307
Khimiya Geterotsiklicheskikh Soedinenii, , vol. 24, # 3 p. 371 - 375
反应条件
1: 88 percent / KOH / methanol / 5 h / Heating 2: 92 percent / 0.03 h / Heating View Scheme
参考文献
Schenone, Pietro; Sansebastiano, Laura; Mosti, Luisa
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 295 - 305
反应条件
potassium hydroxide in methanol 5 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 27, # 2 p. 295 - 305
反应条件
1: 80 percent / aq. NaOH / ethanol / 20 °C 2: 91 percent / (COCl)2; DMF / CH2Cl2 / 20 °C View Scheme
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
