(1-苄基-3-哌啶基)甲醇合成路线 （共 9 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=5°C; 1 h; 2: With ethyl acetate in tetrahydrofuran
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/67401 A1, 2006 ;
Location in patent: Page/Page column 190-191 ;
WO 2006/067401 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60°C;
参考文献
Kobayashi; Inoue; Nishino; Fujihara; Oizumi; Kimura
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 5 p. 797 - 817
反应条件
1: 1.) Na 2.) H2 / 2.) 10percent Pd/C / 1.) EtOH, 2.) EtOH, RT, atm. pressure, 6 h 2: 3.2 g / K2CO3 / acetone / 24 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 1 p. 222 - 225
反应条件
potassium carbonate in acetone 24 h; Ambient temperature;
参考文献
Balsamo, A.; Giorgi, I.; Lapucci, A.; Lucacchini, A.; Macchia, B.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 222 - 225
反应条件
sodium tris(acetoxy)borohydride in dichloromethane
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 7 p. 1711 - 1714
反应条件
lithium aluminium tetrahydride; triethylamine 1.) THF, 48 h, 2.) THF, reflux, 17 h; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 23 p. 4344 - 4361
反应条件
1: 1.4 g / SOCl2, HCl / CHCl3 / 1.5 h / Heating 2: ethanol / 30 h / 100 °C 3: 0.7 g / H2 / 10percent Pd/C / ethanol / 5 h / 50 °C View Scheme
参考文献
Balsamo, A.; Giorgi, I.; Lapucci, A.; Lucacchini, A.; Macchia, B.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 222 - 225
反应条件
hydrogenchloride; thionyl chloride in chloroform 1.5 h; Heating;
参考文献
Balsamo, A.; Giorgi, I.; Lapucci, A.; Lucacchini, A.; Macchia, B.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 222 - 225
