5-溴-2-[(2-硝基乙烯)氨基]-苯甲酸合成路线 （共 9 条）
反应条件
1: acetic anhydride; potassium acetate / 3 h / 120 °C 2: trichlorophosphate / 0.75 h / 120 °C 3: acetic acid / 2 h View Scheme
参考文献
NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo
Patent: WO2013/23119 A1, 2013 ;
反应条件
sodium acetate; acetic anhydride T=120°C; 2 h;
参考文献
INTELLIKINE, LLC; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; WILSON, Troy, Edward; CAMPBELL, Simon, Fraser
Patent: WO2012/116237 A2, 2012 ;
Location in patent: Page/Page column 119 ;
WO 2012/116237 A2
反应条件
potassium acetate T=120°C; 1.5 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/54237 A1, 2005 ;
Location in patent: Page/Page column 53 ;
WO 2005/054237 A1
反应条件
1: acetic anhydride; potassium acetate / 3 h / 120 °C 2: trichlorophosphate / 0.75 h / 120 °C View Scheme
参考文献
NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo
Patent: WO2013/23119 A1, 2013 ;
反应条件
1: 2-amino-5-bromo-benzoic acid With hydrogenchloride in water
8 h;
2: nitromethane With hydrogenchloride; sodium hydroxide in water
T=20°C; 18 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/54237 A1, 2005 ;
Location in patent: Page/Page column 53 ;
WO 2005/054237 A1
参考文献
INTELLIKINE, LLC; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; WILSON, Troy, Edward; CAMPBELL, Simon, Fraser
Patent: WO2012/116237 A2, 2012 ;
Location in patent: Page/Page column 119 ;
WO 2012/116237 A2
反应条件
1: hydrogenchloride / water / 24 h / 20 °C
2: 24 h / 20 °C
View Scheme
参考文献
INTELLIKINE, LLC; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; WILSON, Troy, Edward; CAMPBELL, Simon, Fraser
Patent: WO2012/116237 A2, 2012 ;
WO 2012/116237 A2
反应条件
1: potassium acetate; acetic anhydride / 1.5 h / 120 °C
2: trichlorophosphate / 0.75 h / 120 °C
3: acetic acid / 2 h
4: hydrogen / tetrahydrofuran; methanol / 1 h / 825.08 Torr
5: triethylamine / dichloromethane / 1 h / 0 °C
6: tetrabutylammomium bromide; sodium hydroxide / water; dichloromethane / 72 h / 20 °C
View Scheme
参考文献
NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo
Patent: WO2013/23119 A1, 2013 ;
反应条件
1: acetic anhydride; potassium acetate / 3 h / 120 °C
2: trichlorophosphate / 0.75 h / 120 °C
3: acetic acid / 2 h
4: hydrogen / Raney-nickel / tetrahydrofuran; methanol / 1 h / 20 °C / 1292.9 Torr
View Scheme
参考文献
NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo
Patent: WO2013/23119 A1, 2013 ;
